I recently had the opportunity to do some artwork for the Anchorage United for Youth advertising campaign. They wanted a RSA style comic on short notice, so I ended up doing a motion capture of my artwork using Sketchbook Pro, which was condensed and edited by the ad agency. The taxing thing was that I had to draw it straight through over 20+ minutes without making a mistake.
drawing program: Sketchbook Pro
motion capture: CamStudio (open-source/free)